Folate Intake, Alcohol Consumption, Cigarette Smoking, and Risk of Colorectal Adenomas
نویسندگان
چکیده
منابع مشابه
A prospective study of dietary folate intake and risk of colorectal cancer: modification by caffeine intake and cigarette smoking.
Epidemiologic evidence indicates an inverse association of folate intake with risk of colorectal cancer, but whether this association is modified by intake of caffeine (in coffee and tea) or cigarette smoking--factors that possibly interfere with folate--has not been studied. Thus, we examined whether the association between dietary folate intake and incidence of colorectal cancer is modified b...
متن کاملAlcohol consumption, alcohol dehydrogenase 3 polymorphism, and colorectal adenomas.
Alcohol is a probable risk factor with regard to colorectal neoplasm and is metabolized to the carcinogen acetaldehyde by the genetically polymorphic alcohol dehydrogenase 3 (ADH3) enzyme. We evaluated whether the association between alcohol and colorectal adenomas is modified by ADH3 polymorphism. We recruited 433 cases with adenomatous polyps and 436 polyp-free controls among Caucasians under...
متن کاملCigarette smoking, CYP1A1 MspI and GSTM1 genotypes, and colorectal adenomas.
Cigarette smoking has been related to increased risk of colorectal adenomas, but the underlying mechanisms are unknown. Genetic polymorphisms are known for enzymes involved in the activation of polycyclic aromatic hydrocarbons and other tobacco-related carcinogens. Polycyclic aromatic hydrocarbons are activated by cytochrome P4501A1 (CYP1A1) and detoxified by glutathione S-transferases. We inve...
متن کاملAlcohol Intake, Smoking, and Colorectal Adenoma
BACKGROUND Colorectal cancer is the third most common cancer in Korea. Because colorectal adenoma is a precursor lesion of colorectal cancer, primary prevention of colorectal adenomas may be important for reducing morbidity and mortality from the disease. The aim of this study is to examine the association of alcohol consumption and cigarette smoking in relation with colorectal adenoma in a cro...
متن کاملThymidylate synthase promoter polymorphism, interaction with folate intake, and risk of colorectal adenomas.
Thymidylate synthase (TS) is a key enzyme in folate metabolism and the primary target of 5-fluorouracil. A repeat polymorphism in the TS promoter enhancer region (2rpt versus 3rpt of 28 bp) is associated with decreased expression, and a 6-bp deletion in the 3'untranslated region may affect RNA stability. We investigated the role of TS polymorphisms in a case control study of adenomatous polyps ...
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ژورنال
عنوان ژورنال: JNCI: Journal of the National Cancer Institute
سال: 1998
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/90.1.57